HRID1720502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12072511

未命名化合物

结构：COc1ccc(CNC(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)OCc2ccccc2)cc1

HCID54101220

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CNC(=O)N2CCC[C@H]2C(=O)N2CCC[C@H]2C(=O)C[S@](=O)c2ccc(OC)cc2)cc1

HCID53744324

未命名化合物

收率 31.2%

PROCEDURE

实验过程

By the same procedure as in Example 15-D) using N-(4-methoxybenzylaminocarbonyl)-L-prolyl-L-proline benzyl ester (1.30 g) and (S)-(-)-4-methoxyphenyl methyl sulfoxide (480 mg) as obtained in Example 15-C), there was obtained 460 mg of the title compound as colorless needles (See Table 7).

WORKUP

后处理

customas obtained in Example 15-C), there

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f27fe0b2a204847a7468781a8397036
来源数据集: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05506256
来源说明: uspto-grants-1996_04

反应 SMILES

C([O:8][C:9](=O)[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:33])[C@@H:16]1[CH2:20][CH2:19][CH2:18][N:17]1[C:21]([NH:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=1)=[O:22])C1C=CC=CC=1.[CH3:35][S@@:36]([C:38]1[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=1)=[O:37]>>[CH3:32][O:31][C:28]1[CH:27]=[CH:26][C:25]([CH2:24][NH:23][C:21]([N:17]2[CH2:18][CH2:19][CH2:20][C@H:16]2[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][C@H:10]2[C:9](=[O:8])[CH2:35][S@@:36]([C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=2)=[O:37])=[O:33])=[O:22])=[CH:30][CH:29]=1