HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-4-methoxyphenyl methyl sulfoxide → (2S)-1-[N-(4-Methoxybenzylaminocarbonyl)-L-prolyl]-2-{[(S)-4-methoxyphenylsulfinyl]acetyl}pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-4-methoxyphenyl methyl sulfoxide | HCID 12072511 | — |
| Reactant | N-(4-methoxybenzylaminocarbonyl)-L-prolyl-L-proline benzyl ester | HCID 54101220 | — |
| Product | (2S)-1-[N-(4-Methoxybenzylaminocarbonyl)-L-prolyl]-2-{[(S)-4-methoxyphenylsulfinyl]acetyl}pyrrolidine | HCID 53744324 | 31.2% |
Reaction Steps
By the same procedure as in Example 15-D) using N-(4-methoxybenzylaminocarbonyl)-L-prolyl-L-proline benzyl ester (1.30 g) and (S)-(-)-4-methoxyphenyl methyl sulfoxide (480 mg) as obtained in Example 15-C), there was obtained 460 mg of the title compound as colorless needles (See Table 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-1f27fe0b2a204847a7468781a8397036 |
| Source note | uspto-grants-1996_04 |