HRID1720509

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10354601

L-Proline, 1-(1-oxo-3-phenylpropyl)-

C14H17NO3

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(O)COc1ccc(OCc2ccccc2)cc1

HCID57047086

未命名化合物

PRODUCTS

生成物

结构：O=C(CCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccc(OCc2ccccc2)cc1

HCID67771548

未命名化合物

收率 81.1%

PROCEDURE

实验过程

By the same procedure as in Example 26-D), while using (2S)-2-{2-[4-(benzyloxy)phenoxy]-1-hydroxyethyl}-1-(tert-butoxycarbonyl)pyrrolidine (1.71 g) and N-(3-phenylpropionyl)- L-proline (1.10 g), there was obtained 1.82 g of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6c8a73a5ff1d4967aece35dc15966474
来源数据集: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05506256
来源说明: uspto-grants-1996_04

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:30]=[CH:29][C:12]([O:13][CH2:14][CH:15]([C@@H:17]2[CH2:21][CH2:20][CH2:19][N:18]2[C:22](OC(C)(C)C)=[O:23])[OH:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]1([CH2:37][CH2:38][C:39]([N:41]2[CH2:48][CH2:47][CH2:46][C@H:42]2C(O)=O)=[O:40])[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:1]([O:8][C:9]1[CH:30]=[CH:29][C:12]([O:13][CH2:14][CH:15]([C@@H:17]2[CH2:21][CH2:20][CH2:19][N:18]2[C:22](=[O:23])[C@@H:48]2[CH2:47][CH2:46][CH2:42][N:41]2[C:39](=[O:40])[CH2:38][CH2:37][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[OH:16])=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1