HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Proline, 1-(1-oxo-3-phenylpropyl)- → (2S)-2-{2-[4-(Benzyloxy)phenoxy]-1-hydroxyethyl}-1-[N-(3-phenylpropionyl)-L-prolyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Proline, 1-(1-oxo-3-phenylpropyl)- | HCID 10354601 | — |
| Reactant | (2S)-2-{2-[4-(Benzyloxy)phenoxy]-1-hydroxyethyl}-1-(tert-butoxycarbonyl)pyrrolidine | HCID 57047086 | — |
| Product | (2S)-2-{2-[4-(Benzyloxy)phenoxy]-1-hydroxyethyl}-1-[N-(3-phenylpropionyl)-L-prolyl]pyrrolidine | HCID 67771548 | 81.1% |
Reaction Steps
By the same procedure as in Example 26-D), while using (2S)-2-{2-[4-(benzyloxy)phenoxy]-1-hydroxyethyl}-1-(tert-butoxycarbonyl)pyrrolidine (1.71 g) and N-(3-phenylpropionyl)- L-proline (1.10 g), there was obtained 1.82 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-6c8a73a5ff1d4967aece35dc15966474 |
| Source note | uspto-grants-1996_04 |