HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2S)-2-(1-Hydroxy-2-phenoxyethyl)-1-{N-[3-phenyl-2(S)-(1-piperidinyl)propionyl]-L-prolyl}pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2S)-3-phenyl-2-(1-piperidinyl)propionic acid hydrochloride | HCID 67771413 | — |
| Reactant | (2S)-1-[N-(tert-Butoxycarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine | HCID 70050944 | — |
| Product | (2S)-2-(1-Hydroxy-2-phenoxyethyl)-1-{N-[3-phenyl-2(S)-(1-piperidinyl)propionyl]-L-prolyl}pyrrolidine | HCID 22860067 | 84.9% |
Reaction Steps
The residue obtained by treating, with 4N hydrochloric acid, (2S)-1-[N-(tert-butoxycarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine (751 mg) prepared in Example 46-C) was subjected to condensation with (2S)-3-phenyl-2-(1-piperidinyl)propionic acid hydrochloride (500 mg) in the same manner as in Example 48-B) to give 818 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506256 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-52e902c1fd9d44bca6d0f1dca0759a43 |
| Source note | uspto-grants-1996_04 |