HCID 10629927, compound → HCID 10724543, compound

HRID 1720814Notes

Reaction equation

HRID 1720814 reaction equation
C([O:5][C:6](=[O:72])[C@H:7]([CH2:63][CH2:64][C:65]([O:67]C(C)(C)C)=[O:66])[NH:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:62])[CH2:20][CH2:21][S:22][CH2:23][CH:24]([O:44][C:45](=[O:61])[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH3:60])[CH2:25][O:26][C:27](=[O:43])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[CH:14][CH:13]=1)(=[O:11])=[O:10])(C)(C)C>FC(F)(F)C(O)=O>[C:45]([O:44][CH:24]([CH2:25][O:26][C:27](=[O:43])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:23][S:22][CH2:21][CH2:20][C:19]([NH:18][C:15]1[CH:14]=[CH:13][C:12]([S:9]([NH:8][C@H:7]([C:6]([OH:72])=[O:5])[CH2:63][CH2:64][C:65]([OH:67])=[O:66])(=[O:10])=[O:11])=[CH:17][CH:16]=1)=[O:62])(=[O:61])[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH3:60]

Participants

3

Reactant 1

HCID 10629927HCID 10629927, compound

Product 1

HCID 10724543HCID 10724543, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of (4-(6,7-bis(palmitoyloxy)-4-thiaheptanoylamino)benzenesulfonyl)glutamic acid di-t-butyl ester as obtained in Example 19 (213 mg) in trifluoroacetic acid (5 ml) was stirred at room temperature for 4 hours and then concentrated to yield the title compound (190 mg, yield 100% ) as a colorless crystal.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-113f9d5d80cf48ac930561395681e2ff
Source dataset
uspto-grants-1996_04
Patent number
US05506267

Reaction notes

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