Trifluoroacetic acid → HCID 54031326, compound

HRID 1720816Notes

Reaction equation

HRID 1720816 reaction equation
C([O:5][C:6](=[O:70])[C@H:7]([CH2:62][C:63]([O:65]C(C)(C)C)=[O:64])[NH:8][C:9](=[O:61])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:60])[CH2:18][CH2:19][S:20][CH2:21][CH:22]([O:42][C:43](=[O:59])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58])[CH2:23][O:24][C:25](=[O:41])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])=[CH:12][CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O>>[C:43]([O:42][CH:22]([CH2:23][O:24][C:25](=[O:41])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:21][S:20][CH2:19][CH2:18][C:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([NH:8][C@H:7]([C:6]([OH:70])=[O:5])[CH2:62][C:63]([OH:65])=[O:64])=[O:61])=[CH:11][CH:12]=1)=[O:60])(=[O:59])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54390515HCID 54390515, compound

Product 1

HCID 54031326HCID 54031326, compoundYield 97%

Procedure

To (4-(6,7-bis(palmitoyloxy)-4-thiaheptanoylamino)benzoyl)aspartic acid di-t-butyl ester as obtained in Example 21 (197 mg), trifiuoroacetic acid (5 ml) was added, followed by stirring at room temperature for 4 hours. The mixture was concentrated to yield the title compound (170 mg, yield 97%) as a colorless crystal.

Workup

  1. additionwas added
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-7a35890602ad43269ac3e40b2927b79b
Source dataset
uspto-grants-1996_04
Patent number
US05506267

Reaction notes

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