HCID 53760659, compound → HCID 53849187, compound

HRID 1720829Notes

Reaction equation

HRID 1720829 reaction equation
C([O:5][C:6](=[O:76])[C@H:7]([CH2:67][CH2:68][C:69]([O:71]C(C)(C)C)=[O:70])[NH:8][C:9](=[O:66])[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18](=[O:65])[CH2:19][CH2:20][S:21][CH2:22][CH:23]([O:45][C:46](=[O:64])[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)[CH2:24][O:25][C:26](=[O:44])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[CH:12][CH:11]=1)(C)(C)C>FC(F)(F)C(O)=O>[C:58]1([CH2:57][CH2:56][CH2:55][CH2:54][CH2:53][CH2:52][CH2:51][CH2:50][CH2:49][CH2:48][CH2:47][C:46]([O:45][CH:23]([CH2:24][O:25][C:26](=[O:44])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH2:22][S:21][CH2:20][CH2:19][C:18]([NH:17][CH2:16][C:13]2[CH:14]=[CH:15][C:10]([C:9]([NH:8][C@H:7]([C:6]([OH:76])=[O:5])[CH2:67][CH2:68][C:69]([OH:71])=[O:70])=[O:66])=[CH:11][CH:12]=2)=[O:65])=[O:64])[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1

Participants

3

Reactant 1

HCID 53760659HCID 53760659, compound

Product 1

HCID 53849187HCID 53849187, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 4-[6,7-bis(12-phenyldodecanoyloxy)-4-thiaheptanoylaminomethyl]benzoyl-glutamic acid di-t-butyl ester as obtained in Example 58 (255 mg) in trifluoroacetic acid (2 ml) was stirred at room temperature for 2 hours, after which the solvent was distilled off under reduced pressure, to yield the title compound (200 mg, yield 88%) as a syrup.

Workup

  1. distillationafter which the solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-fceb8a1cb06b49b78b7c9a80609c7bf9
Source dataset
uspto-grants-1996_04
Patent number
US05506267

Reaction notes

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