HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-(1,3-bis(t-butyloxycarbonyl)propyl)isoindolin-1-one → 5-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-(1,3-bis(hydroxycarbonyl)propyl)isoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-(1,3-bis(t-butyloxycarbonyl)propyl)isoindolin-1-one | HCID 22418593 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5-(6,7-Bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-(1,3-bis(hydroxycarbonyl)propyl)isoindolin-1-one | HCID 22418640 | 100% |
Reaction Steps
A solution of 5-(6,7-bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-(1,3-bis(t-butyloxycarbonyl)propyl)isoindolin-1-one as obtained in Example 62 (208 mg) in trifluoroacetic acid (5 ml) was stirred at room temperature for 4 hours, followed by concentration, to yield the title compound (191 mg, yield 100%) as a colorless crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05506267 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-ea52a99348174b5aa36963271dfa5a67 |
| Source note | uspto-grants-1996_04 |