HRID1720833

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)Nc1ccc2c(c1)CN(C(CCC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C2=O)OC(=O)CCCCCCCCCCCCCCC

HCID22418593

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCC(=O)OCC(CSCCC(=O)Nc1ccc2c(c1)CN(C(CCC(=O)O)C(=O)O)C2=O)OC(=O)CCCCCCCCCCCCCCC

HCID22418640

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

A solution of 5-(6,7-bis(palmitoyloxy)-4-thiaheptanoyl)amino-2-(1,3-bis(t-butyloxycarbonyl)propyl)isoindolin-1-one as obtained in Example 62 (208 mg) in trifluoroacetic acid (5 ml) was stirred at room temperature for 4 hours, followed by concentration, to yield the title compound (191 mg, yield 100%) as a colorless crystal.

WORKUP

后处理

concentrationfollowed by concentration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ea52a99348174b5aa36963271dfa5a67
来源数据集: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05506267
来源说明: uspto-grants-1996_04

反应 SMILES

[C:1]([O:18][CH:19]([CH2:54][O:55][C:56](=[O:72])[CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH3:71])[CH2:20][S:21][CH2:22][CH2:23][C:24]([NH:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[C:32](=[O:36])[N:31]([CH:37]([C:47]([O:49]C(C)(C)C)=[O:48])[CH2:38][CH2:39][C:40]([O:42]C(C)(C)C)=[O:41])[CH2:30]2)=[O:25])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>FC(F)(F)C(O)=O>[C:1]([O:18][CH:19]([CH2:54][O:55][C:56](=[O:72])[CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH3:71])[CH2:20][S:21][CH2:22][CH2:23][C:24]([NH:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[C:32](=[O:36])[N:31]([CH:37]([C:47]([OH:49])=[O:48])[CH2:38][CH2:39][C:40]([OH:42])=[O:41])[CH2:30]2)=[O:25])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]