Sodium Hydroxide → HCID 86749437, compound

HRID 1720850Notes

Reaction equation

HRID 1720850 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([O:17][C:14]2([CH3:16])[CH3:15])[C:9]([O:11]CC)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+:19]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([O:17][C:14]2([CH3:15])[CH3:16])[C:9]([O-:11])=[O:10])=[CH:6][CH:7]=1.[Na+:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22416474HCID 22416474, compound

Product 1

HCID 86749437HCID 86749437, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 2-(4-chlorophenyl)-2,3-epoxy-3-methylbutanoate (3.05 g, 12 mmol), prepared in Example 1d, and sodium hydroxide (0.48 g, 12 mmol) in absolute ethanol (40 ml) was refluxed for 11/2 hours. After cooling to room temperature, the precipitate was filtered off and the filtrate was evaporated in vacuo to give a residue. The precipitate and the residue from evaporation were combined and washed with isopropyl ether to give the product (2.40 g, 80%) as white crystals.

Workup

  1. temperaturewas refluxed for 11/2 hours
  2. filtrationthe precipitate was filtered off
  3. customthe filtrate was evaporated in vacuo
  4. customto give a residue
  5. customThe precipitate and the residue from evaporation
  6. washwashed with isopropyl ether

Sources & evidence

ORD record
ord-002371691afa40d9af6fc677f59cff27
Source dataset
uspto-grants-1996_04
Patent number
US05508251

Reaction notes

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