Sodium Hydroxide → HCID 86749437, compound

Participants

Reaction Steps

A solution of ethyl 2-(4-chlorophenyl)-2,3-epoxy-3-methylbutanoate (3.05 g, 12 mmol), prepared in Example 1d, and sodium hydroxide (0.48 g, 12 mmol) in absolute ethanol (40 ml) was refluxed for 11/2 hours. After cooling to room temperature, the precipitate was filtered off and the filtrate was evaporated in vacuo to give a residue. The precipitate and the residue from evaporation were combined and washed with isopropyl ether to give the product (2.40 g, 80%) as white crystals.

Provenance & Evidence