Allylamine → HCID 10649615, compound

Participants

Reaction Steps

3 g of 4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylamino]piperidine are added to a solution of 1.15 g of 9-allyl-2,6-dichloropurine in 20 ml of ethanol and the mixture is stirred for 3 hours at room temperature and then for 30 minutes at 50° C. The mixture is then treated as described in Example 1. The residue obtained is recrystallised from ether. 1.8 g of white crystals melting (cap) at 146°-148° C. are obtained. By proceeding as in Example 1, starting from 1.8 g of the 2-chloropurine compound so obtained dissolved in 20 ml of butanol and heated to 150° C. in the presence of 0.6 ml of allylamine, 0.7 g of 9-allyl-2-allylamino-6-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylamino]piperidino}purine is obtained in the form of a resinous product of which the difumarate, recrystallised from ethanol, melts (cap) at 191°-194° C.

Provenance & Evidence