反应详情

A mixture of 2,6-dichloro-3-nitrobenzoic acid (4.72 g, 0.02 mol), 4-tertbutylaniline (4.47 g, 0.03 mol), lithium carbonate (1.48 g, 0.02 mol), and 1-propanol (10 mL) was refluxed with stirring for 20 h. The solvent was evaporated and to the residue, water (30 mL) and benzene (50 mL) were added. The mixture was made strongly basic with sodium hydroxide and stirred for 1h. Orange precipitate was collected by filtration and washed with benzene and ether. Dry precipitate was dissolved in water and acidified with diluted hydrochloric acid. Resulting precipitate was collected and crystallized from acetone-water to give 4.55 (65%) of the desired product, mp 201°-204° C. Anal. (C31H27N7O6) C, H, N.

1. temperaturewas refluxed
2. customThe solvent was evaporated and to the residue, water (30 mL) and benzene (50 mL)
3. additionwere added
4. stirringstirred for 1h
5. filtrationOrange precipitate was collected by filtration
6. washwashed with benzene and ether
7. customDry precipitate
8. dissolutionwas dissolved in water
9. customResulting precipitate
10. customwas collected
11. customcrystallized from acetone-water