Dichloromethane → HCID 22416524, compound

HRID 1720880Notes

Reaction equation

HRID 1720880 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[CH:6]=[CH:5]2.[C:12](C1NC=CN=1)(C1NC=CN=1)=[O:13].ClCCl.[NH2:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[CH:34]=[N:33][CH:32]=[CH:31]2>CN(C=O)C>[CH3:11][N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:12]([NH:27][C:28]3[CH:29]=[C:30]4[C:35](=[CH:36][CH:37]=3)[CH:34]=[N:33][CH:32]=[CH:31]4)=[O:13])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 5889916-AminoisoquinolineHCID 27695641-methyl-1H-indol-5-amineHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

Product 1

HCID 22416524HCID 22416524, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared using standard methodology as described herein, such as reaction of (D2) with carbonyl diimidazole in a solvent such as dry dichloromethane, and reacting the product with 6-aminoisoquinoline in a solvent such as DMF, with heating.

Workup

  1. temperaturewith heating

Sources & evidence

ORD record
ord-6277e47c4d4e465d9a50247cbfcccb8e
Source dataset
uspto-grants-1996_04
Patent number
US05508288

Reaction notes

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