反应详情

温度

0 °C

3-Cyano-5-methylpyridine (2 g, 16.9 mmol) was dissolved in 1-propanol (100 ml). Sodium methoxide (46 mg, 0.85 mmol) was added, and the resulting mixture was stirred at 0° C. for 20 hours. After the completion of the reaction, the reaction mixture was neutralized with acetic acid (56 mg, 0.93 mmol), and the resulting mixture was concentrated under reduced pressure. After concentration, ethyl ether (50 ml) was added to the residue, and insoluble sodium acetate was removed by filtration. The filtrate was concentrated under reduced pressure to give a crude product of propyl 5-methyl-3-pyridinecarboximidate.

1. customAfter the completion of the reaction
2. concentrationthe resulting mixture was concentrated under reduced pressure
3. concentrationAfter concentration, ethyl ether (50 ml)
4. additionwas added to the residue, and insoluble sodium acetate
5. customwas removed by filtration
6. concentrationThe filtrate was concentrated under reduced pressure