Cyanamide → HCID 10420446, compound

HRID 1720909Notes

Reaction equation

HRID 1720909 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8](=[NH:13])[O:9][CH2:10][CH2:11][CH3:12])[CH:5]=[N:6][CH:7]=1.[NH2:14][C:15]#N>C(#N)C>[NH2:1][C:2]1[CH:3]=[C:4]([C:8](=[N:13][C:15]#[N:14])[O:9][CH2:10][CH2:11][CH3:12])[CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 9864CyanamideHCID 10103743HCID 10103743, compound

Product 1

HCID 10420446HCID 10420446, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The propyl 5-amino-3-pyridinecarboximidate (110 mg, 0.6 mmol) was then dissolved in acetonitrile (1 ml), and an aqueous solution (2 ml) of NaH2PO4 ·2H2O(375 mg, 2.4 mmol), Na2HPO4 (85 mg, 0.6 mmol) and NH2CN (50 mg, 1.2 mmol) was added to the solution. The mixture was stirred at room temperature for 19 hours. After the completion of the reaction, the reaction mixture was extracted with chloroform (20 ml×3), and the chloroform layer was dried over- anhydrous sodium sulfate and concentrated under reduced pressure to give a crude oil of propyl 5-amino-N-cyano-3-pyridinecarboximidate (100 mg, yield 82%).

Workup

  1. customAfter the completion of the reaction
  2. extractionthe reaction mixture was extracted with chloroform (20 ml×3)
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-dabe5aca23f940afa606b9a850d28775
Source dataset
uspto-grants-1996_04
Patent number
US05508293

Reaction notes

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