Cyanamide → HCID 10420446, compound

Participants

Reaction Steps

The propyl 5-amino-3-pyridinecarboximidate (110 mg, 0.6 mmol) was then dissolved in acetonitrile (1 ml), and an aqueous solution (2 ml) of NaH2PO4 ·2H2O(375 mg, 2.4 mmol), Na2HPO4 (85 mg, 0.6 mmol) and NH2CN (50 mg, 1.2 mmol) was added to the solution. The mixture was stirred at room temperature for 19 hours. After the completion of the reaction, the reaction mixture was extracted with chloroform (20 ml×3), and the chloroform layer was dried over- anhydrous sodium sulfate and concentrated under reduced pressure to give a crude oil of propyl 5-amino-N-cyano-3-pyridinecarboximidate (100 mg, yield 82%).

Provenance & Evidence