Hydrochloric Acid → HCID 178479449, compound

HRID 1721004Notes

Reaction equation

HRID 1721004 reaction equation
[ClH:1].Cl.C([O:7][CH:8](OCCCC)[C@H:9]([CH2:40][CH2:41][CH2:42][NH:43][C:44](=[NH:46])[NH2:45])[NH:10][C:11](=[O:39])[C@H:12]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[NH:13][C:14](=[O:31])[C@H:15]1[CH2:19][CH2:18][C:17](=[O:20])[N:16]1[C:21]([O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22])CCC.[OH-].[Na+]>C(#N)C>[ClH:1].[CH2:24]([O:23][C:21]([N:16]1[C:17](=[O:20])[CH2:18][CH2:19][C@@H:15]1[C:14]([NH:13][C@H:12]([C:11]([NH:10][C@H:9]([CH:8]=[O:7])[CH2:40][CH2:41][CH2:42][NH:43][C:44](=[NH:45])[NH2:46])=[O:39])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31])=[O:22])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178450977HCID 178450977, compound

Product 1

HCID 178479449HCID 178479449, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

After 1N hydrochloric acid aqueous solution (5 ml) was added to a solution of N-benzyloxycarbonyl-D-pyroglutamyl-L-phenylalanyl-L-argininal dibutylacetal hydrochloride (72 mg, 0.10 mmol) in acetonitrile (10 ml), the mixture was reacted at 36° C. for 1.5 hour with stirring. After completion of the reaction, pH of the reaction mixture was adjusted to 4.8 with 1N sodium hydroxide aqueous solution. The solvent was distilled off under reduced pressure and chloroform was added to the residue. Insoluble matters were removed by filtration. After the filtrate was concentrated, the residue was recrystallized from chloroform-hexane to give 44 mg (75%) of N-benzyloxycarbonyl-D-pyroglutamyl-L-phenylalanyl-L-argininal hydrochloride.

Workup

  1. customthe mixture was reacted at 36° C. for 1.5 hour
  2. customAfter completion of the reaction, pH of the reaction mixture
  3. distillationThe solvent was distilled off under reduced pressure and chloroform
  4. additionwas added to the residue
  5. customInsoluble matters were removed by filtration
  6. concentrationAfter the filtrate was concentrated
  7. customthe residue was recrystallized from chloroform-hexane

Sources & evidence

ORD record
ord-b08b736cefd84a6fb90c41d133abe44c
Source dataset
uspto-grants-1996_04
Patent number
US05508385

Reaction notes

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