Dimethylformamide → HCID 86749440, compound

HRID 1721124Notes

Reaction equation

[OH:1][CH2:2][C:3]1[S:4][C:5](I)=[CH:6][CH:7]=1.CN(C)[CH:11]=[O:12]>>[OH:1][CH2:2][C:3]1([C:3]2[S:4][CH:5]=[CH:6][CH:7]=2)[CH2:7][CH:6]=[C:5]([CH2:11][OH:12])[S:4]1

Participants

Reactant 2

HCID 6228Dimethylformamide

HCID 14296055(5-Iodothiophen-2-yl)methanol

Product 1

HCID 86749440HCID 86749440, compound

Procedure

2-hydroxymethyl-5-iodothiophene was refluxed with Cu powder in dimethyl formamide ("DMF"). This Ullmann condensation also yielded a very low amount of 2,5-dihydroxymethyl bithiophene.

Workup

customThis Ullmann condensation

Sources & evidence

ORD record: ord-172825c6595c493b9833971201a1ce23
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05508440

Reaction notes

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