反应详情

温度

78 °C

420.5 g of 4-amino-2-nitroanisole are dissolved in 1275 ml of diethylene glycol dimethyl ether and 150 ml of water, 135 g of calcium carbonate are added and the mixture is heated to 78° C. 375 g of 2-chloroethyl chloroformate are allowed to run into this mixture in the course of 3 hours such that the reaction temperature remains at 78°-80° C. The mixture is subsequently stirred for 1.5 hours to bring the reaction to completion and is cooled to 35° C. and water and ice are added. The product which has precipitated is filtered off, washed with water and dried.

1. customto run into this mixture in the course of 3 hours such that the reaction temperature
2. customremains at 78°-80° C
3. customthe reaction to completion
4. temperatureis cooled to 35° C.
5. customThe product which has precipitated
6. filtrationis filtered off
7. washwashed with water
8. customdried