2,2-Diethylbutanedioic acid → 4-[3-(7-Benzyloxy-2-quinolinylmethoxy)phenylamino]-2,2-diethyl-4-oxobutanoic acid

HRID 1721175Notes

Reaction equation

HRID 1721175 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([CH2:19][O:20][C:21]3[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=3)[NH2:24])=[N:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:28]([C:30]([CH2:38][CH3:39])([CH2:34][C:35](O)=[O:36])[C:31]([OH:33])=[O:32])[CH3:29].[K+].[Br-]>>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([CH2:19][O:20][C:21]3[CH:22]=[C:23]([NH:24][C:35](=[O:36])[CH2:34][C:30]([CH2:38][CH3:39])([CH2:28][CH3:29])[C:31]([OH:33])=[O:32])[CH:25]=[CH:26][CH:27]=3)=[N:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 1385662,2-Diethylbutanedioic acidHCID 253877Potassium BromideHCID 224169073-(7-Benzyloxy-2-quinolinylmethoxy)aniline

Product 1

HCID 224168714-[3-(7-Benzyloxy-2-quinolinylmethoxy)phenylamino]-2,2-diethyl-4-oxobutanoic acid

Procedure

Analogously to Example 3, the title compound is prepared starting from 3-(7-benzyloxy-2-quinolinylmethoxy)aniline and 2,2-diethylsuccinic acid. Slightly yellowish crystals of m.p. 89°-95° are obtained; IR (KBr): 3325, 2966, 1689, 1599, 1545, 1512, 1492, 1436, 1380, 1208, 1157, 1024, 842, 775, 695 cm-1.

Workup

  1. customSlightly yellowish crystals of m.p. 89°-95° are obtained

Sources & evidence

ORD record
ord-2f1ed7585b724bcaabee9866c4f12fc6
Source dataset
uspto-grants-1996_04
Patent number
US05508408

Reaction notes

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