2,2-Dimethylsuccinic anhydride → 4-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2,2-dimethyl-4-oxobutanoic acid

HRID 1721187Notes

Reaction equation

HRID 1721187 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:7][C:6](=[O:8])[O:5][C:3]1=[O:4].[F:10][C:11]1[CH:20]=[C:19]2[C:14]([CH:15]=[CH:16][C:17]([CH2:21][O:22][C:23]3[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=3)[NH2:26])=[N:18]2)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:20]=[C:19]2[C:14]([CH:15]=[CH:16][C:17]([CH2:21][O:22][C:23]3[CH:24]=[C:25]([NH:26][C:6](=[O:8])[CH2:7][C:2]([CH3:9])([CH3:1])[C:3]([OH:5])=[O:4])[CH:27]=[CH:28][CH:29]=3)=[N:18]2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 870672,2-Dimethylsuccinic anhydrideHCID 224168723-(7-Fluoro-2-quinolinylmethoxy)aniline

Product 1

HCID 224169034-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2,2-dimethyl-4-oxobutanoic acid

Procedure

The title compound is prepared analogously to the compound described in Example 20 from 2,2-dimethylsuccinic acid anhydride and 3-(7-fluoro-2-quinolinylmethoxy)aniline; colourless crystals of m.p. 209°-210°.

Sources & evidence

ORD record
ord-d1fa32135de046898af85b3c1464cc5b
Source dataset
uspto-grants-1996_04
Patent number
US05508408

Reaction notes

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