2-Ethyl-2-methylsuccinic anhydride → 4-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2-ethyl-2-methyl-4-oxobutanoic acid

HRID 1721188Notes

Reaction equation

HRID 1721188 reaction equation
[CH2:1]([C:3]1([CH3:10])[CH2:8][C:7](=[O:9])[O:6][C:4]1=[O:5])[CH3:2].[F:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH2:22][O:23][C:24]3[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=3)[NH2:27])=[N:19]2)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][C:18]([CH2:22][O:23][C:24]3[CH:25]=[C:26]([NH:27][C:7](=[O:9])[CH2:8][C:3]([CH2:1][CH3:2])([CH3:10])[C:4]([OH:6])=[O:5])[CH:28]=[CH:29][CH:30]=3)=[N:19]2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 30165332-Ethyl-2-methylsuccinic anhydrideHCID 224168723-(7-Fluoro-2-quinolinylmethoxy)aniline

Product 1

HCID 224168834-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2-ethyl-2-methyl-4-oxobutanoic acid

Procedure

The title compound is prepared analogously to the compound described in Example 20 from 2-ethyl-2-methylsuccinic acid anhydride and 3-(7-fluoro-2-quinolinylmethoxy)aniline; colourless crystals of m.p. 179°-180°.

Sources & evidence

ORD record
ord-615aa3c442704ab2a7a02e932bb9a75c
Source dataset
uspto-grants-1996_04
Patent number
US05508408

Reaction notes

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