Hydrochloric Acid → HCID 67746333, compound

HRID 1721201Notes

Reaction equation

HRID 1721201 reaction equation
[ClH:1].C(OC([N:9]1[CH2:17][CH:16]2[CH:11]([C:12]([F:31])([F:30])[CH2:13][CH2:14][C:15]2([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[C:24]1([C:15]2([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:14][CH2:13][C:12]([F:31])([F:30])[CH:11]3[CH:16]2[CH2:17][NH:9][CH2:10]3)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67808955HCID 67808955, compound

Product 1

HCID 67746333HCID 67746333, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

20 cm3 of dioxane and 20 cm3 of 6.3N hydrochloric acid are added to 1.8 g of (3aRS, 7aRS)-2-tert-butyloxycarbonyl-4,4-diphenyl-7,7difluoroperhydroisoindole. After stirring for 20 hours at room temperature, the white suspension obtained is concentrated to dryness at 40° C. under reduced pressure (2.7 kPa). The residue is washed with diisopropyl oxide, the solid obtained is drained and then dried. 1.51 g of (3aRS, 7aRS)-4,4-diphenyl-7,7-difluoroperhydroisoindole hydrochloride are obtained in the form of a white solid.

Workup

  1. customthe white suspension obtained
  2. concentrationis concentrated to dryness at 40° C. under reduced pressure (2.7 kPa)
  3. washThe residue is washed with diisopropyl oxide
  4. customthe solid obtained
  5. customdried

Sources & evidence

ORD record
ord-95b1df8fc9504d00b18d96630c2a3e6d
Source dataset
uspto-grants-1996_04
Patent number
US05508433

Reaction notes

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