Pyridine → HCID 22414241, compound

HRID 1721264Notes

Reaction equation

HRID 1721264 reaction equation
N1C=CC=CC=1.[CH2:7]([S:10][C:11]1[N:15]=[CH:14][NH:13][N:12]=1)[C:8]#[CH:9].[CH2:16]([N:18]([CH2:22][CH3:23])[C:19](Cl)=[O:20])[CH3:17]>O>[CH2:16]([N:18]([CH2:22][CH3:23])[C:19]([N:13]1[CH:14]=[N:15][C:11]([S:10][CH2:7][C:8]#[CH:9])=[N:12]1)=[O:20])[CH3:17]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6916Diethylcarbamoyl chlorideHCID 178460803HCID 178460803, compound

Product 1

HCID 22414241HCID 22414241, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 31.5 ml of pyridine was added 5.56 g of 3-(2-propynylthio)-1H-1,2,4-triazole and then 6.3 ml of diethylcarbamyl chloride. The resulting mixture was stirred under nitrogen at ambient temperature for 3 days and was then poured into 350 ml of cold water with agitation. The precipitate was collected by filtration, washed with water air dried and then dried in oven to give 8.1 g of the title compound as a solid. m.p. 67°-69° C. NMR (CDCl3): 1.3 (t, 6H); 2,21 (t. 1H); 3.62 (m, 4H); 3.88 (d, 2H); 8.78 (s, 1H).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water air
  3. customdried
  4. customdried in oven

Sources & evidence

ORD record
ord-b892dea1b6654d13a3df86492ffcf96c
Source dataset
uspto-grants-1996_04
Patent number
US05510320

Reaction notes

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