Pyrrolidine → HCID 19428541, compound

HRID 1721295Notes

Reaction equation

HRID 1721295 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:3]=1.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>>[Cl:8][C:6]1[CH:7]=[C:2]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[N:3]=[C:4]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])[N:5]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 194285024,6-Dichloro-N-(1,1-dimethylethyl)-2-pyrimidinamine

Product 1

HCID 19428541HCID 19428541, compoundYield 93%

Procedure

4,6-Dichloro-2-(1,1-dimethylethylamino)pyrimidine is reacted with pyrrolidine as described in Example 28 to give the title compound in a yield of 93%, m p.: 153°-157° C.

Sources & evidence

ORD record
ord-263181ec140749e99dec40110b50b716
Source dataset
uspto-grants-1996_04
Patent number
US05510345

Reaction notes

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