Piperazine → HCID 19429145, compound

HRID 1721299Notes

Reaction equation

HRID 1721299 reaction equation
[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][NH:4][C:5]1[N:10]=[C:9](Cl)[CH:8]=[C:7]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[N:6]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][NH:4][C:5]1[N:10]=[C:9]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:8]=[C:7]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[N:6]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 19428538HCID 19428538, compound

Product 1

HCID 19429145HCID 19429145, compoundYield 76%

Procedure

The reaction of 2-(2,2-dimethylpropylamino)-4-chloro-6-pyrrolidinopyrimidine with piperazine as described in Example 17 leads to the title compound in a yield of 76%, m.p.: 118°-120° C.

Sources & evidence

ORD record
ord-d89bcb59e4504ce89722d3e2d9598907
Source dataset
uspto-grants-1996_04
Patent number
US05510345

Reaction notes

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