反应详情

A solution of 4-bromo-3-methylbenzonitrile (20.0 g) in methanol (100 ml) was treated with hydroxylamine hydrochloride (4×2.08 g) and potassium t-butoxide (4×3.25 g) over 6 hours and the resulting mixture heated at reflux for 18 h. After cooling, the reaction mixture was poured into water (800 ml), the suspension stirred for 30 min, and the white solid filtered off and dried in vacuo to give the title compound (21.2 g).

1. temperaturethe resulting mixture heated
2. temperatureat reflux for 18 h
3. temperatureAfter cooling
4. filtrationthe white solid filtered off
5. customdried in vacuo