HCID 22218187, compound → 143224-95-7

HRID 1721399Notes

Reaction equation

HRID 1721399 reaction equation
[CH3:1][S:2]([CH2:5][C:6](=[CH2:10])[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]>CO.[Pd]>[CH3:10][CH:6]([CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[C:7]([OH:9])=[O:8]

Participants

4

Reactant 1

HCID 22218187HCID 22218187, compound

Product 1

HCID 22142344143224-95-7Yield 96,328,664%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-(methylsulfonylmethyl) acrylicacid (700 mg, 4.26 nmol) in 20 mL of methanol was chargedinto a Fisher-Porter bottle along width 10% palladium oncarbon catalyst under a nitrogen atmosphere. The reactionvessel was sealed and flushed five times with nitrogen andthen five times with hydrogen. The pressure wasmaintained at 50 psig for 16 h and then the hydrogen wasreplaced with nitrogen and the solution filtered through apad of celite to remove the catalyst and the filtrateconcentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid.

Workup

  1. customThe reactionvessel was sealed
  2. customflushed five times with nitrogen andthen five times with hydrogen
  3. filtrationthe solution filtered through apad of celite
  4. customto remove the catalyst

Sources & evidence

ORD record
ord-d37924ea097f4f3d80e482ae622cb59c
Source dataset
uspto-grants-1996_04
Patent number
US05510378

Reaction notes

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