HCID 22218187, compound → 143224-95-7

Participants

Reaction Steps

A solution of 2-(methylsulfonylmethyl) acrylicacid (700 mg, 4.26 nmol) in 20 mL of methanol was chargedinto a Fisher-Porter bottle along width 10% palladium oncarbon catalyst under a nitrogen atmosphere. The reactionvessel was sealed and flushed five times with nitrogen andthen five times with hydrogen. The pressure wasmaintained at 50 psig for 16 h and then the hydrogen wasreplaced with nitrogen and the solution filtered through apad of celite to remove the catalyst and the filtrateconcentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid.

Provenance & Evidence