反应详情

The above urethane phthalimide was treated with 1 equiv anhydrous hydrazine in isopropanol for 18 h at room temperature followed by 4 h reflux. The mixture was concentrated, diluted with cold aqueous acetic acid and filtered to remove phthalazinedione. The aqueous layer was basified with NaOH followed by extraction with ethyl acetate, drying, and evaporation to afford the desired product as a solid. mp 118-121

1. temperaturereflux
2. concentrationThe mixture was concentrated
3. additiondiluted with cold aqueous acetic acid
4. filtrationfiltered
5. customto remove phthalazinedione
6. extractionfollowed by extraction with ethyl acetate
7. customdrying
8. customevaporation