Methanol → Nonane

Participants

Reaction Steps

Following the procedure of Example 1, 2- 4-fluorobenzoyl!amino!-4-thiazoleacetic acid (1.10 g, 3.93 mmol) was allowed to react with N-(4-aminobutyl)-3-azabicyclo 3.2.2.!-nonane (0.77 g, 3.13 mmol) for 24 hours to give after flash column chromatography on silica gel eluting with 15% methanol in ethyl acetate, the title compound (0.79 g, 57%). The hydrochloride salt was prepared with ethereal HCl to give a tan powder after recrystallization from ethyl acetate and hexane: m.p. 220°-222° C.

Provenance & Evidence