Methanol → Nonane

HRID 1721441Notes

Reaction equation

HRID 1721441 reaction equation
S1[CH:5]=[C:4]([CH2:6][C:7](O)=O)N=C1.S1[CH:14]=[C:13]([C:15](O)=O)N=C1.CO.[C:20](OCC)(=O)[CH3:21]>>[CH3:7][CH2:6][CH2:4][CH2:5][CH2:15][CH2:13][CH2:14][CH2:20][CH3:21]

Participants

5

Reactant 4

HCID 887MethanolHCID 8857Ethyl AcetateHCID 2362624-Thiazoleacetic acidHCID 3042714-Thiazolecarboxylic acid

Product 1

HCID 8141Nonane

Procedure

Following the procedure of Example 1, 2- 4-fluorobenzoyl!amino!-4-thiazoleacetic acid (1.10 g, 3.93 mmol) was allowed to react with N-(4-aminobutyl)-3-azabicyclo 3.2.2.!-nonane (0.77 g, 3.13 mmol) for 24 hours to give after flash column chromatography on silica gel eluting with 15% methanol in ethyl acetate, the title compound (0.79 g, 57%). The hydrochloride salt was prepared with ethereal HCl to give a tan powder after recrystallization from ethyl acetate and hexane: m.p. 220°-222° C.

Sources & evidence

ORD record
ord-1a1cd8da5f494e318538bb680a47227a
Source dataset
uspto-grants-1996_04
Patent number
US05510478

Reaction notes

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