Hydrochloric Acid → HCID 19972019, compound

HRID 1721498Notes

Reaction equation

HRID 1721498 reaction equation
[ClH:1].C1(C(C2C=CC=CC=2)=[N:9][CH:10]([P:18]([CH:23]([N:31]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:22])[O:19][CH2:20][CH3:21])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)C=CC=CC=1>CCOCC>[ClH:1].[NH2:31][CH:23]([P:18]([CH:10]([NH2:9])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:22])[O:19][CH2:20][CH3:21])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11006844HCID 11006844, compound

Product 1

HCID 19972019HCID 19972019, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Approximately 10% strength aqueous hydrochloric acid (30 ml) is added to a solution of the bis-alkylated phosphinate 5 (1161 mg; 1.76 mmol) in ether (30 ml) at room temperature with stirring. After 24 hours the organic phase is separated off and the aqueous phase is extracted with ethyl acetate (20 ml). The phosphinate hydrochloride 10 (690 mg, 97% of theory) is obtained after freeze-drying.

Workup

  1. customAfter 24 hours the organic phase is separated off
  2. extractionthe aqueous phase is extracted with ethyl acetate (20 ml)

Sources & evidence

ORD record
ord-2ba30a1010c947a39f1f133cc31aa74b
Source dataset
uspto-grants-1996_04
Patent number
US05510504

Reaction notes

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