Hydrochloric Acid → HCID 22415605, compound

HRID 1721500Notes

Reaction equation

HRID 1721500 reaction equation
C(OC([NH:8][CH2:9][P:10]([CH2:14][NH:15]C(OC(C)(C)C)=O)(=[O:13])[O:11][CH3:12])=O)(C)(C)C.[ClH:23]>>[ClH:23].[NH2:8][CH2:9][P:10]([CH2:14][NH2:15])(=[O:13])[O:11][CH3:12]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22415602HCID 22415602, compound

Product 1

HCID 22415605HCID 22415605, compound

Procedure

The tert-butoxycarbonyl protective group of the methyl phosphinate 17 (2.470 g; 7.31 mmol) is removed using 3N. methanolic hydrochloric acid (50 ml ), by analogy with Example 4. The methyl phosphinate hydrochloride 18 is obtained (1.522 g, 99% of theory).

Sources & evidence

ORD record
ord-3b88c3c130904228b205c1f7c58cb50f
Source dataset
uspto-grants-1996_04
Patent number
US05510504

Reaction notes

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