1-Chloro-2,4,6-trifluorobenzene → 1,3,5-Trifluorobenzene

HRID 1721514Notes

Reaction equation

HRID 1721514 reaction equation
Cl[C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[F:10]>[Cu].O>[F:8][C:7]1[CH:2]=[C:3]([F:10])[CH:4]=[C:5]([F:9])[CH:6]=1

Participants

4

Reactant 1

HCID 27366621-Chloro-2,4,6-trifluorobenzene

Product 1

HCID 97451,3,5-TrifluorobenzeneYield 73%

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 962WaterSolvent

Conditions

Temperature
300 °C

Procedure

An autoclave was charged with 66.8 g of 2-chloro-1,3,5-trifluorobenzene, 5 g of water and 65 g of copper powder, and the content was heated at 300° C. with high speed stirring for 28 hours. After the reaction, the content was distilled off, and the fraction distilled at 74° to 77° C. was collected and dried over sodium sulfate to obtain 1,3,5-trifluorobenzene in an amount of 38.5 g (yield 73%).

Workup

  1. customAfter the reaction
  2. distillationthe content was distilled off
  3. distillationthe fraction distilled at 74° to 77° C.
  4. customwas collected
  5. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-ac4b01011aac41659487e486ddda1a3f
Source dataset
uspto-grants-1996_04
Patent number
US05510533

Reaction notes

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