1-Chloro-2,4,6-trifluorobenzene → 1,3,5-Trifluorobenzene

Participants

Reaction Conditions

Reaction Steps

An autoclave was charged with 66.8 g of 2-chloro-1,3,5-trifluorobenzene, 5 g of water and 65 g of copper powder, and the content was heated at 300° C. with high speed stirring for 28 hours. After the reaction, the content was distilled off, and the fraction distilled at 74° to 77° C. was collected and dried over sodium sulfate to obtain 1,3,5-trifluorobenzene in an amount of 38.5 g (yield 73%).

Provenance & Evidence