Hydrochloric Acid → HCID 86748345, compound

HRID 1721575Notes

Reaction equation

HRID 1721575 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:22](=[O:29])([O:26]CC)[O:23]CC)[P:14](=[O:21])([O:18]CC)[O:15]CC.[ClH:30]>>[ClH:30].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:22](=[O:23])([OH:26])[OH:29])[P:14](=[O:15])([OH:18])[OH:21]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15230149HCID 15230149, compound

Product 1

HCID 86748345HCID 86748345, compoundYield 70%

Procedure

A solution of tetraethyl 4-(2-pyridylthio)butylaminomethylenebisphosphonate (2.50 g) in hydrochloric acid (40 ml) was stirred for 3 hours under reflux. The reaction mixture was concentrated under reduced pressure. Acetone was added to the residue and the separated white precipitate was collected by filtration and recrystallized from water-methanol to obtain 4-(2-pyridylthio)butylaminomethylenebisphosphonic acid hydrochloride (1.46 g, 70%) as white powder.

Workup

  1. temperatureunder reflux
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionAcetone was added to the residue
  4. filtrationthe separated white precipitate was collected by filtration
  5. customrecrystallized from water-methanol

Sources & evidence

ORD record
ord-74cf34d28886445e957c6861280feb23
Source dataset
uspto-grants-1996_04
Patent number
US05512552

Reaction notes

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