6-Chloro-3-(4-benzyloxyphenyl)pyridazine → 3-(4-Benzyloxyphenyl)-6-(6-octyloxypyridin-3-yl)pyridazine

HRID 1721586Notes

Reaction equation

HRID 1721586 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:22]([O:30][C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][N:32]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:15]([O:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[N:6]=[N:7][C:2]([C:34]3[CH:33]=[N:32][C:31]([O:30][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:36][CH:35]=3)=[CH:3][CH:4]=2)=[CH:9][CH:10]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 224126306-Chloro-3-(4-benzyloxyphenyl)pyridazineHCID 224127982-Octyloxy-5-pyridineboronic acid

Product 1

HCID 224129383-(4-Benzyloxyphenyl)-6-(6-octyloxypyridin-3-yl)pyridazineYield 69.3%

Procedure

In accordance with scheme D, 14 g (47.2 mmol) of 6-chloro-3-(4-benzyloxyphenyl)pyridazine are reacted analogously to Example 4a with 11.8 g (47.2 mmol) of 2-octyloxypyridine-5-boronic acid to give 15.3 g of 3-(4-benzyloxyphenyl)-6-(6-octyloxypyridin-3-yl)pyridazine.

Sources & evidence

ORD record
ord-1db1615caf5e4ca49c7eeaddec9730db
Source dataset
uspto-grants-1996_04
Patent number
US05512207

Reaction notes

Loading…