2,5-Dichloropyrazine → 2-Chloro-5-(4-benzyloxyphenyl)pyrazine

HRID 1721587Notes

Reaction equation

HRID 1721587 reaction equation
Cl[C:2]1[CH:7]=[N:6][C:5]([Cl:8])=[CH:4][N:3]=1.[CH2:9]([O:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Cl:8][C:5]1[CH:4]=[N:3][C:2]([C:20]2[CH:21]=[CH:22][C:17]([O:16][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:18][CH:19]=2)=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 3362242,5-DichloropyrazineHCID 27343144-Benzyloxy-phenylboronic acid

Product 1

HCID 538787932-Chloro-5-(4-benzyloxyphenyl)pyrazine

Procedure

In accordance with scheme C-I, 30 g (201 mmol) of 2,5-dichloropyrazine and 45.92 g (201 mmol) of 4-benzyloxyphenylboronic acid are coupled analogously to Example 4a to give 2-chloro-5-(4-benzyloxyphenyl)pyrazine.

Sources & evidence

ORD record
ord-37353ad561064ec8abb31eda9b64e040
Source dataset
uspto-grants-1996_04
Patent number
US05512207

Reaction notes

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