Benzene → 3-Benzoylpyridine-2-carboxylic acid

HRID 1721599노트

반응식

HRID 1721599 반응식
[N:1]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:2]=1[C:3]([O:5][C:6]2=[O:11])=[O:4].[Al+3].[Cl-].[Cl-].[Cl-].[CH:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:6]([C:7]1[C:2]([C:3]([OH:5])=[O:4])=[N:1][CH:10]=[CH:9][CH:8]=1)(=[O:11])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 3

HCID 241BenzeneHCID 69688Furo[3,4-b]pyridine-5,7-dioneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 7269413-Benzoylpyridine-2-carboxylic acid

실험 절차

10 g (67 mmol) quinolinic acid anhydride was suspended in 50 ml benzene and 17.9 g (134 mmol) AlCl3 was added in portions while cooling on ice. After completion of the addition, it was stirred for a further 3 hours at room temperature, carefully admixed with ice and aspirated from the precipitate which was present. The crude product was purified by column chromatography on silica gel 60 using ethyl acetate/dichloromethane 1/1 as the eluent.

후처리

  1. temperaturewhile cooling on ice
  2. additionAfter completion of the addition, it
  3. customThe crude product was purified by column chromatography on silica gel 60 using ethyl acetate/dichloromethane 1/1 as the eluent

출처 및 근거

ORD 기록
ord-cb8b0a94163740858d6ea364cff5334b
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05512564

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