Benzene → 3-Benzoylpyridine-2-carboxylic acid

HRID 1721599ノート

反応式

HRID 1721599 の反応式
[N:1]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:2]=1[C:3]([O:5][C:6]2=[O:11])=[O:4].[Al+3].[Cl-].[Cl-].[Cl-].[CH:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:6]([C:7]1[C:2]([C:3]([OH:5])=[O:4])=[N:1][CH:10]=[CH:9][CH:8]=1)(=[O:11])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 3

HCID 241BenzeneHCID 69688Furo[3,4-b]pyridine-5,7-dioneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 7269413-Benzoylpyridine-2-carboxylic acid

実験手順

10 g (67 mmol) quinolinic acid anhydride was suspended in 50 ml benzene and 17.9 g (134 mmol) AlCl3 was added in portions while cooling on ice. After completion of the addition, it was stirred for a further 3 hours at room temperature, carefully admixed with ice and aspirated from the precipitate which was present. The crude product was purified by column chromatography on silica gel 60 using ethyl acetate/dichloromethane 1/1 as the eluent.

後処理

  1. temperaturewhile cooling on ice
  2. additionAfter completion of the addition, it
  3. customThe crude product was purified by column chromatography on silica gel 60 using ethyl acetate/dichloromethane 1/1 as the eluent

出典と根拠

ORDレコード
ord-cb8b0a94163740858d6ea364cff5334b
出典データセット
uspto-grants-1996_04
特許番号
US05512564

反応ノート

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