4-(Methylthio)phenylacetyl chloride → 4-(4-Methylthiophenylacetyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride

HRID 1721626Notes

Reaction equation

HRID 1721626 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:13][S:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([Cl:24])=[O:23])=[CH:17][CH:16]=1>C(N(CC)CC)C>[ClH:24].[CH3:13][S:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([N:8]2[CH2:9][CH2:10][S:11][CH2:12][CH:7]2[CH2:6][N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:23])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 150201874-(Methylthio)phenylacetyl chlorideHCID 157301473-(Pyrrolidin-1-ylmethyl)thiomorpholine

Product 1

HCID 676252984-(4-Methylthiophenylacetyl)-3-(pyrrolidin-1-ylmethyl)thiomorpholine hydrochloride

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 17 was repeated, but using 1.0 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 1.38 ml of triethylamine and 1.2 of 4-methylthiophenylacetyl chloride, to afford 1.38 g of the title compound, melting at 162°-166° C. (dec.).

Sources & evidence

ORD record
ord-4dfcab3fecba4daab7d2dfeaa5e4f2fb
Source dataset
uspto-grants-1996_04
Patent number
US05512567

Reaction notes

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