Methyl iodide → HCID 178504025, compound

HRID 1721672Notes

Reaction equation

HRID 1721672 reaction equation
[C:1]([NH:4][CH2:5][C:6]1[O:10][C:9]([C:11]2[N:12]=[C:13]([NH:16][C:17]([NH2:19])=[S:18])[S:14][CH:15]=2)=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH3:20][I:21]>CO>[IH:21].[C:1]([NH:4][CH2:5][C:6]1[O:10][C:9]([C:11]2[N:12]=[C:13]([NH:16][C:17](=[NH:19])[S:18][CH3:20])[S:14][CH:15]=2)=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 10709059HCID 10709059, compound

Product 1

HCID 178504025HCID 178504025, compoundYield 84.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 4-(5-acetylaminomethylfuran-2-yl)-2-thioureidothiazole (12.6 g) and methyl iodide (7.2 g) in methanol (200 ml) was refluxed for 5.5 hours. The solvent was removed under reduced pressure. The residue was washed with ethyl acetate to afford 4-(5-acetylaminomethylfuran-2-yl)-2-(2-methylisothioureido)thiazole hydriodide (15.7 g).

Workup

  1. temperaturewas refluxed for 5.5 hours
  2. customThe solvent was removed under reduced pressure
  3. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-a23747c3f8d44b70808a00ae50cf0334
Source dataset
uspto-grants-1996_04
Patent number
US05512588

Reaction notes

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