反应详情

0.31 g of 2-acetamidoacrylic acid was stirred in 200 ml of 40% methylamine in water at 40° C. for 80 hours. Excess methylamine and water were evaporated under reduced pressure, and the residue was held under high vacuum overnight. The residue was recrystallized from a 1:1 v:v mixture of ether and methanol and dried to give 2-acetylamino-3-(methylamino)propionic acid (38A) as a white solid, m.p.: 166.5°-168.5° C. (with decomposition).

1. customExcess methylamine and water were evaporated under reduced pressure
2. customwas held under high vacuum overnight
3. customThe residue was recrystallized from a 1:1 v
4. additionv mixture of ether and methanol
5. customdried