HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → {1-Azabicyclo[2.2.2]octan-3-yl}methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Azabicyclo(2.2.2)octane-3-carbonitrile | HCID 142865 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | {1-Azabicyclo[2.2.2]octan-3-yl}methanamine | HCID 12603059 | — |
Reaction Steps
A solution of 3-cyanoquinuclidine (3.0g) was added to a stirred suspension of LiAlH4 (1.1g) in dry THF (250ml) and the reaction heated to reflux for 3h. On cooling the reaction, water (1ml), 2.5N NaOH solution (1.5ml) and then water (2.5ml) were added carefully and the solids removed by filtration. Evaporation of the filtrate gave the title compound, D1 (3.1g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04853376 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-2a4ed43c3b7645fea56bdf1be2364109 |
| Source note | uspto-grants-1989_08 |