反应详情

A solution of 3-cyanoquinuclidine (3.0g) was added to a stirred suspension of LiAlH4 (1.1g) in dry THF (250ml) and the reaction heated to reflux for 3h. On cooling the reaction, water (1ml), 2.5N NaOH solution (1.5ml) and then water (2.5ml) were added carefully and the solids removed by filtration. Evaporation of the filtrate gave the title compound, D1 (3.1g) as an oil.

1. temperaturethe reaction heated
2. temperatureto reflux for 3h
3. temperatureOn cooling
4. customthe solids removed by filtration
5. customEvaporation of the filtrate