Ammonia → HCID 13851885, compound

HRID 1721842Notes

Reaction equation

HRID 1721842 reaction equation
[CH2:1]([N:8]([C:13]1[N:21]=[CH:20][N:19]=[C:18]2[C:14]=1[N:15]=[CH:16][N:17]2C1CCCCO1)[CH2:9][CH:10]([CH3:12])[CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.N>O>[CH2:1]([N:8]([C:13]1[N:21]=[CH:20][N:19]=[C:18]2[C:14]=1[NH:15][CH:16]=[N:17]2)[CH2:9][CH:10]([CH3:12])[CH3:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 13851884HCID 13851884, compound2×

Product 1

HCID 13851885HCID 13851885, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 17.0 g. (47 mmole) 6-[N-benzyl-N-(2-methylpropyl)-amino]-9-tetrahydropyran-2-ylpurine (compound of Example 1) in 200 ml. saturated ethanolic hydrogen chloride solution is heated under reflux for 10 minutes. After standing overnight, the reaction mixture is diluted with water, adjusted to pH 7 with aqueous ammonia solution and the precipitate filtered off with suction. After recrystallization from aqueous propan-2-ol, there are obtained 10.5 g. of the title compound (80% of theory); m.p. 160°-162° C.

Workup

  1. temperatureunder reflux for 10 minutes
  2. filtrationthe precipitate filtered off with suction
  3. customAfter recrystallization from aqueous propan-2-ol, there
  4. customare obtained 10.5 g

Sources & evidence

ORD record
ord-e37135a6003a45a89a213559da615eba
Source dataset
uspto-grants-1989_08
Patent number
US04853386

Reaction notes

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