Methylamine → HCID 20029986, compound

HRID 1721849Notes

Reaction equation

HRID 1721849 reaction equation
[CH2:1]([N:4]([C:11]1[N:19]=[C:18](Cl)[N:17]=[C:16]2[C:12]=1[N:13]=[CH:14][N:15]2[CH:21]1[CH2:25][CH2:24][CH2:23][O:22]1)[CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH:2]=[CH2:3].[CH3:26][NH2:27]>CO>[CH2:1]([N:4]([C:11]1[N:19]=[C:18]([NH:27][CH3:26])[N:17]=[C:16]2[C:12]=1[N:13]=[CH:14][N:15]2[CH:21]1[CH2:25][CH2:24][CH2:23][O:22]1)[CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20029971HCID 20029971, compound

Product 1

HCID 20029986HCID 20029986, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 8.5 g. (22 mmole) 6-(N-allyl-N-cyclohexylamino)-2-chloro-9-tetrahydrofuran-2-ylpurine and 150 ml. methanol, which has been saturated with methylamine, is heated to 100° C. in an autoclave for 48 hours. The reaction mixture is then evaporated, the residue is taken up in dichloromethane, washed with water, dried and evaporated. After chromatography with dichloromethane, there are obtained 6.4 g. of the title compound (82% of theory) in the form of an oil.

Workup

  1. additionA mixture of 8.5 g
  2. customThe reaction mixture is then evaporated
  3. washwashed with water
  4. customdried
  5. customevaporated
  6. customAfter chromatography with dichloromethane, there are obtained 6.4 g

Sources & evidence

ORD record
ord-a7b0c86d791740e1baa9d745e69317af
Source dataset
uspto-grants-1989_08
Patent number
US04853386

Reaction notes

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