HRID1721883

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6996

2-Chlorobenzaldehyde

C7H5ClO

HCID18187175

未命名化合物

HCID20070378

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1=C(COCCn2c(C)nc3ccccc32)NC2=C(C(=O)C(C)(C)CC2)C1c1ccccc1Cl

HCID20070376

未命名化合物

收率 11.5%

PROCEDURE

实验过程

The title compound (63 mg) was prepared from 2-chlorobenzaldehyde (202 mg), 3-amino-6,6-dimethyl-2-cyclohexene-1-one (200 mg) and ethyl 4-[2-(2-methylbenzimidazol-1-yl)ethoxy]-3-oxobutanoate (304 mg) by the method of Example 1. M.p. 118°-120° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-262517c8ace145999a97499803e8ae06
来源数据集: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04853392
来源说明: uspto-grants-1989_08

反应 SMILES

[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[NH2:10][C:11]1[CH2:16][CH2:15][C:14]([CH3:18])([CH3:17])[C:13](=[O:19])[CH:12]=1.[CH3:20][C:21]1[N:25]([CH2:26][CH2:27][O:28][CH2:29][C:30](=O)[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:24]2[CH:38]=[CH:39][CH:40]=[CH:41][C:23]=2[N:22]=1>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]1[C:12]2[C:13](=[O:19])[C:14]([CH3:18])([CH3:17])[CH2:15][CH2:16][C:11]=2[NH:10][C:30]([CH2:29][O:28][CH2:27][CH2:26][N:25]2[C:24]3[CH:38]=[CH:39][CH:40]=[CH:41][C:23]=3[N:22]=[C:21]2[CH3:20])=[C:31]1[C:32]([O:34][CH2:35][CH3:36])=[O:33]